Some guidelines have advised against the use of AFP in the diagnosis of HCC. If caught early it can sometimes be.
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In addition AFP is also an indicator of HCC risks mostly in patients with cirrhosis and HCVHBV infections.
Afp hepatocellular carcinoma. It is a glycoprotein produced by the fetal liver and yolk sac during pregnancy. Among the study population 96. AFP level is elevated in 60 of patients with HCC typically those with the most advanced disease.
It is concluded that AFP is a significant markers for Hepatocellular carcinoma helpful in assessing problems in management of HCC and monitoring treatment regiments. AFP is serum glycoprotein produced by fetal yolk sac and fetal liver tissue and it drops rapidly after the birth under 10ngmL. Symptoms and signs are usually nonspecific.
Therefore AFP is the most used marker for detecting HCC. Its different from secondary liver cancers which have spread to the liver from other organs. Hepatocellular carcinoma HCC is the fourth leading cause of cancer-related death worldwide.
Hepatocellular carcinoma usually occurs in patients with cirrhosis and is common in areas where infection with hepatitis B and C viruses is prevalent. As a diagnostic criteria of HCC the exact threshold of Alpha-fetoprotein AFP is controversial. Alphafetoprotein AFP is the most widely accepted serum biomarker used in the management of hepatocellular carcinoma HCC.
Hepatocellular carcinoma HCC has become a pressing health problem facing the world today due to its high morbidity high mortality and late discovery. The sensitivity ranges from. Hepatocellular carcinoma is responsible for over 12000 deaths per year in the United States where the incidence of the disease is approximately 25 per 100000 population.
A median follow-up of 654IQR 13-114 months recurrence occurred in 648 70108 patients. Mild elevations may occur in patients with chronic hepatitis without HCC. Diagnosis is based on alpha-fetoprotein AFP levels imaging tests and sometimes liver biopsy.
Therefore AFP levels are also frequently elevated in chronic active hepatitis. AFP can be normal in significant number of patients with HCC. The first serologic assay for detection and clinical followup of patients with hepatocellular carcinoma was alpha-fetoprotein AFP which has been the standard tumor biomarker for HCC for many years.
The role of serum α-fetoprotein AFP measurements in the diagnosis of hepatocellular carcinoma HCC remains controversial. Hepatocellular carcinoma is a tumor of the liver. One hundred and eight patients fulfilled the inclusions criteria.
The regulation and pathophysiology of AFP informs the basis for its clinical relevance in the context of HCC. 16 rows Patients can be screened for hepatocellular carcinoma using AFP. Alpha-fetoprotein AFP is the standard serum tumor marker utilized in the evaluation of suspected hepatocellular carcinoma.
Although the current application of immunotherapy for HCC is still on trial immunotherapy has achieved certain effect in the treatment of liver cancer. AFP plays an important role in the development of hepatocellular carcinoma which can serve as a target for immunotherapy of HCC. Hepatocellular carcinoma HCC is expected to become a leading cause for liver transplantation LT following curative treatment for hepatitis C and after more widespread acceptance of the practice of tumour down-staging for patients originally considered beyond LT criteria.
1 Many clinical factors are important in the prognosis of patients with HCC including disease stage. Hepatocellular carcinoma is a cancer that starts in your liver. HCC cells produce AFP and the serum level of AFP is usually increased in patients with HCC.
It is one of the most common malignancies in adults and is more common in men than women 2-41 and blacks than whites. The secondary end points were overall survival OS and disease-free RESULTS. AFP levels may be elevated because of production by the tumor or by regenerating hepatocytes.
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